Method and device for supply of a dialysis unit with dialysis fluid

ABSTRACT

A method and a device for supply of a dialyser in a dialysis unit with dialysis fluid is disclosed. At least one dialysis fluid concentrate is mixed with water to produce the dialysis fluid. The dialysis fluid concentrate is prepared in a reservoir unit in a given amount. A control and arithmetic unit calculates the dialysis fluid rate (Qd) such that, after a given treatment time (T B ) has passed, a given residual amount of dialysis fluid concentrate or no residual amount remains in the reservoir unit. It is preferable to empty the reservoir unit by the end of treatment.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No.10/543,174, filed Jul. 22, 2005, which is a national stage applicationof PCT/EP2004/00188, filed Jan. 14, 2004, which claims priority ofGerman Patent Application No. DE 10302691.6, filed Jan. 24, 2003, all ofwhich are incorporated herein by reference in their entireties.

FIELD OF THE INVENTION

The invention relates to a procedure and equipment for supplying adialysis unit with dialysing fluid.

BACKGROUND OF THE INVENTION

It is customary today to use pre-prepared dialysing fluid concentratesto produce dialysing fluid for haemodialysis units, whereby theconcentrate is diluted with water in the dialysis unit. In dialysiscenters, dialysing fluid concentrates are made available either aspre-prepared products in canisters or bags or they are delivered via aring piping system from a central tank.

The dialysing fluid is fed to the dialyser of the dialysis unit, whichis divided by a semi-permeable membrane into a dialysing fluid chamberand a blood chamber. While the patient's blood flows continuouslythrough the blood chamber, the dialysing fluid flows continuously as acounter-current through the dialysing fluid chamber.

Dialysing fluid concentrates supplied from a central source are easy tohandle but have the disadvantage that they cannot be matched to theneeds of an individual patient. Concentrates not provided from a centralsource permit adjustment of the dialysing fluid to suit individualpatients but they must then be delivered to the dialysis unit incanisters or bags for each instance of dialysis treatment. In a normalsituation it is necessary to use a canister with 5 or 6 litres of acidconcentrate and a bag containing 650 to 750 g of sodium bicarbonate.

Since centrally-prepared concentrates can be drawn upon as necessary, noresidual material arises, whereas pre-prepared concentrates intended foronly a single treatment tend not to be used up. However, correctdisposal of the packaging materials by granulation or combustion is onlypossible after the canister or bag has been completely emptied with theconsequence that any residual material left in the canister or in thebag after treatment must be discarded. Furthermore, the disposal of theexcess quantity of concentrate to waste constitutes a material loss.

A variety of types of equipment for the preparation of the dialysingfluid from concentrates and water is known. U.S. Pat. No. 4,895,657, forexample, describes proportioning equipment in which two fluidconcentrates are made available in concentrate containers, each fluidthen being mixed and diluted with water in a pre-set ratio. Normally theconcentrates are described as “35-fold”, i.e. to a given volume ofconcentrate sufficient water is added so that the total volume is 35times that of the concentrate. In practice this means that 1 part byvolume of concentrate and 34 parts by volume of water are mixedtogether.

SUMMARY

An object of the invention is to provide a procedure for supplying thedialyser of a dialysis unit with dialysing fluid which permits thedialysing fluid to be prepared in accordance with the specific need ofthe patient.

A further object of the invention is that of producing equipmentpermitting the provision of a dialysing fluid which is oriented towardsthe needs of individual patients.

In the case of the procedure or the equipment in accordance with theinvention at least one dialysing fluid concentrate is made available inat least one receiving unit. Such receiving units may be, for example,containers, bags or the like.

The procedure or the equipment in accordance with the invention is basedupon the principle that the rate of flow of the dialysing fluid duringthe dialysis treatment is so arranged that at the end of the treatment apre-set residual amount of the dialysing fluid concentrate remains inthe receiving unit or, alternatively, that the receiving unit iscompletely empty. In this context, the adjustment of the rate of flow ofthe dialysing fluid is related to the pre-set quantity of dialysingfluid concentrate at the commencement of the dialysis treatment, thepre-set volumetric ratio between the dialysing fluid concentrate andwater and the pre-set duration of the treatment. The rate of flow of thedialysing fluid may remain constant during the treatment period or itmay be varied.

The procedure or the equipment in accordance with the invention rendersit possible to adjust the rate of flow of the dialysing fluid to a levelwhich lies above the minimum rate necessary for the treatment so thatthe overall level of dialysance is increased.

In a conventional dialysis treatment, the doctor prescribes a particulardose level of dialysis by specifying appropriate rates of flow for theblood and the dialysing fluid for a particular type of dialyser as wellas an appropriate treatment time. In practice, the quantities ofconcentrates made available are determined in such a manner that ingeneral they are adequate for treatments with different dialysing fluidrates. Consequently, in practice the concentrate is not completely usedup. The procedure or the equipment in accordance with the inventionmakes use of the residual amount of concentrate to permit a higher rateof flow of the dialysing fluid. This has the advantage that when ahigher rate of flow is used, the dialysing dose rate is increased whichhas a beneficial effect upon the treatment. For example, the efficiencyof a hollow fiber dialyser increases with increasing rates of flow ofdialysing fluids up to an asymptotic limiting value.

For the reasons identified above, in principle an effort is made toensure that the dialysing fluid in the receiving unit is used up by theend of the treatment. In practice, however, it can be useful inindividual instances to control the rate of flow of the dialysing fluidin such a manner that a pre-set residual volume of dialysing fluidconcentrate should still remain in the receiving unit to provide areserve. For example, such a reserve may be necessary if the treatmentis interrupted once or more often because of complications and when forthe period of the interruption the dialysing fluid flows to waste.

The pre-set residual quantity of concentrate can then be used to preparethe dialysing fluid in a quantity necessary for an appropriate extensionof the treatment, thus ensuring that the effective length of treatmentis attained.

Preferably, the pre-set residual volume of dialysing fluid is dischargedto waste at the end of the treatment so that the receiving unit iscompletely empty. Preferably, the pre-set residual dialysing fluid isdiluted with water in a pre-set volumetric ratio to ensure that thediluted concentrate may be discharged to waste without causing anyproblems.

The pre-set volume of dialysing fluid concentrate, the pre-setvolumetric ratio and the pre-set treatment time can be entered manuallyor they may be scanned in automatically. For example, the data may berecorded in the form of a bar code on the containers or bags and readoff by means of a reading device.

In a preferred embodiment of the procedure or the equipment inaccordance with the invention, the flow rate of the dialysing fluid overthe full duration of the treatment is determined before the commencementof the dialysis treatment from the pre-set quantity of dialysing fluidconcentrate at the beginning of the treatment, the pre-set volumetricratio of the concentrate and water and the pre-set treatment time. Therate of flow of the dialysing fluid can then be set for the total periodof the treatment time in such a manner that there remains in thereceiving unit either no concentrate or the pre-set residual volume.

An alternative embodiment provides for the initial setting of a pre-setdialysing fluid flow rate for a pre-set time interval which should forma substantial part of the overall dialysis treatment, the dialysingfluid flow rate which is to be set for the remaining treatment timebeing determined only at the end of the pre-set time interval such thatat the end of the treatment the receiving unit contains either noresidual dialysing fluid concentrate or the pre-set residual volume. Toachieve this, following the end of the pre-set time intervaldetermination is made of the flow rate based on the remaining dialysingfluid concentrate in the receiving unit, the pre-set volumetric ratioand the remaining treatment time. The amount of dialysing fluidconcentrate in the receiving unit is determined from the pre-set volumeof concentrate at the beginning of the dialysis treatment and the amountof dialysing fluid concentrate used. If the proportioning activity isperformed by a pump providing a constant relationship between the numberof operating cycles, i.e. piston strokes, revolutions or the like andthe volume conveyed, the quantity of dialysing fluid concentrate usedcan be calculated in a simple manner regardless of any externaloperating conditions. In the event of one or more interruptions to thedialysis treatment during the pre-set time interval the treatment timecan be lengthened by a corresponding amount and then the optimal flowrate of dialysing fluid can be determined on the basis of the increasein treatment time.

If several concentrates in several receiving units are employed, aresidual amount can only be pre-set for one of the receiving units ifthe receiving units have different capacities and the volumetric ratiosof concentrate and water are different. In that situation, thecalculation of the flow rate of the dialysing fluid should then be madeon the basis of the pre-set volume of concentrate in the receiving unitwhich is the first to be fully used.

Various types of dialysis equipment provide for a test to be carried outover a pre-set time interval before the dialysis treatment commences. Todetermine the pre-set amount of dialysing fluid concentrate at thecommencement of the dialysis treatment a calculation is made using thequantity of dialysing fluid concentrate in the receiving unit before thetest and the quantity of dialysing fluid concentrate used during thepre-set time interval in order to determine the quantity of concentratein the receiving unit before commencement of the dialysis treatment.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a very simplified schematic representation of equipment forsupplying a dialyser of a dialysis unit together with the dialysingequipment.

FIGS. 2 a and 2 b show the volume of concentrate or the rate of flow ofthe dialysing fluid as a function of time for a first exemplaryembodiment of the invention.

FIGS. 3 a and 3 b show the volume of concentrate or the rate of flow ofthe dialysing fluid as a function of time for a second exemplaryembodiment of the invention.

DETAILED DESCRIPTION

In the following, two embodiment examples of the procedure and theequipment in accordance with the invention are explained in more detailby reference to the drawings.

The haemodialysis equipment exhibits a dialyser 1 which is divided intoa blood chamber 3 and a dialysing fluid chamber 4 by a semi-permeablemembrane 2. The inlet to the blood chamber 3 is connected to one end ofblood supply pipe 5 in line with a blood pump 6 while the outlet of theblood chamber is connected to the end of a blood return pipe 7. Adialysing fluid supply pipe 8 leads to the inlet of the dialysing fluidchamber 4 and from the outlet of the dialysing fluid chamber a dialysingfluid outflow pipe 9 leads to a waste discharge 10. A dialysing fluidpump 11 is in line with the dialysing fluid outflow pipe 9. During thecourse of the dialysis treatment, the patient's blood flows through theblood chamber 3 of the dialyser 1 while a counterflow of dialysing fluidpasses through the dialysing fluid chamber 4.

In general, the equipment for supplying the dialyser with dialysingfluid is a component part of the dialysis unit. In principle, however,the supply equipment may also be a separate unit. There follows adetailed description of the supply equipment.

To prepare the dialysing fluid, two concentrates K1 and K2 are mixedwith water in a pre-set ratio by volume. Examples of the directionsgiven for this dilution consist of a “35-fold” or “45-fold” ratio, i.e.one part by volume of the concentrate is mixed with 34 or 44 parts byvolume of water. When a dry concentrate in powder form is used insteadof a fluid concentrate the weight of the powder is first converted to anequivalent volume of fluid concentrate in order that the concentrate maybe mixed with water in accordance with the pre-set volumetric ratio.

The supply equipment contains two receiving units for the twoconcentrates; one of these is a canister 12 which is filled with 5 or 6litres of acid concentrate and the other is a bag 13 which is filledwith 650 to 750 g of sodium bicarbonate.

A first concentrate pipe 14 connects the canister 12 with mixing chamber15 and a second concentrate pipe 16 connects the bag 13 to the mixingchamber 15. Proportioning pumps 17 and 18 are connected intorespectively the first and second concentrate pipes 14 and 16.Furthermore, a water supply pipe 19 connected to a source of water 38feeds into the mixing chamber 15. A proportioning pump 20 is alsoconnected into the water supply pipe 19.

The proportioning pumps 17, 18 and 20 are connected by data and controlleads 21, 22 and 23 to a central control and calculating unit 24, whichinstructs the proportioning pumps to operate at particular rates of flowso that the concentrates and water are mixed in a pre-set volume ratioto produce the dialysing fluid in the mixing chamber 15. The bag 13containing the dry concentrate possesses a water inlet 46 through whicha specified volume of water passes. In order to obtain a fluidconcentrate from the dry concentrate—by mixing with water in a pre-setvolumetric ratio—the powder is first dissolved in water which enters thebag via the water inlet.

In addition, the supply equipment possesses an input unit 25 whichcommunicates with the central control and calculating unit 24 by a datalead 39.

An emptying pipe 26 runs from the canister 12 and connects with a secondmixing chamber 27 while a second emptying pipe 28 runs from the bag 13and is connected to the mixing chamber 27. A water pipe 29 connects thesource of water with the mixing chamber 27. In the first and secondemptying pipes 26 and 28 and in the water pipe 29 there are respectivelyintegrated pumps 30, 31 and 32 which are connected via control leads 33,34 and 35 with the central control and calculating unit 24. A wastedischarge pipe 36 runs from the mixing chamber 27 to the waste dischargeoutlet 10.

To facilitate an interruption of the dialysis treatment, for example ifcomplications develop or if it is necessary to carry out a test the unitis fitted with a by-pass pipe 41 with a by-pass valve 40 together withan up-stream stop-valve 42 and a down-stream stop valve 43 with respectto the dialysing fluid chamber 4 of the dialyser 1. If the dialysistreatment is interrupted, the dialysing fluid flows through the by-passpipe 41 into the waste discharge pipe 10 which means that there is noflow of dialysing fluid through the dialysing fluid chamber 4.

The haemodialysis unit is also provided with a central control andcalculating unit 44, which communicates by a data lead 45 with thecontrol and calculating unit 24 of the supply equipment.

There now follows a detailed description of the method of functioning ofthe supply equipment.

In a first embodiment, the control and calculating unit 24 of the supplyequipment controls the operation of the pumps in such a manner that thefollowing process steps are carried out.

Before the dialysis treatment commences, the quantities M₁ and M₂ offluid concentrate within the canister 12 and the bag 13, respectively,are entered into the data input unit 25. Furthermore, the data relatingto the effective treatment time Tb together with the volumetric ratioV₁, V₂ of concentrate K1 or K2, respectively, and water W are alsoentered into the data input unit 25.

To prepare the dialysing fluid which is to be fed to the dialyser 1, thecontrol and calculating unit 24 sets the flow rates of the proportioningpumps 17, 18 and 20 such that the concentrates K1 and K2 are each mixedin the mixing chamber with water in the pre-set volumetric ratio.

During the course of an initial test and preparation phase the controland calculation unit 44 of the dialysis unit closes the stop valves 42,43 and opens the by-pass valve 40 so that the dialysing fluid flowsthrough the by-pass pipe 41 to the waste outlet 10 for a pre-set timeinterval T_(test) The flow rate of dialysing fluid amounts, for example,to Qd_(t). At the end of the time interval T_(test) the effectivedialysis treatment commences.

The control and calculation unit 24 now calculates the quantity ofconcentrate which was used during the time interval T_(test) from thepre-set rates of flow of the proportioning pumps 17 and 18. From thedifferences between the pre-set concentrate quantities M1, M2 and theamount of concentrate used during the time interval T_(test) the controland calculation unit 24 now determines the quantity of concentrateremaining in the container 12 or the bag 13 at the time the effectivedialysis treatment commences.

The attempt should be made during the course of the dialysis treatmentto ensure that, if at all possible, both receiving units should becompletely emptied. In practice, however, this is not possible if thecontents of the canister 12 and the bag 13 are not in the precisedesired relationship to one another. Therefore, the control andcalculation unit selects the receiving unit which is to be completelyemptied. In the present exemplary embodiment, it is assumed that it isthe canister 12 which is to be emptied completely. In principle, ofcourse, it can also be decided that a pre-set residual volume should beretained in the canister 12. The cited decisions are, of course, onlygiven by way of example. Thus, the control and calculation unit 24 canprescribe which receiving unit is to be emptied completely in such amanner that the smallest possible residual quantity should be left inthe other receiving unit.

The control and calculating unit 24 now calculates the dialysis flowrate Q_(d) which is required to ensure that there is no residual volumeof concentrate in the canister at the end of the treatment time; to dothis it uses the quantity M_(t1) of the concentrate remaining in thecanister 12 at the beginning of the effective dialysis treatment afterthe test at time point t₁, the pre-set duration of the treatment T_(B)and the pre-set volumetric relationship V₁ of the acid concentrate K1and water W. The instruction for this rate of flow of the dialysingfluid is transmitted via the data lead 45 to the control and calculationunit 44 of the dialysis unit, which then sets the corresponding supplyrate of the dialysing fluid pump 11.

FIGS. 2 a and 2 b show the volume M of the concentrate in the canister12 and the flow rate of the dialysing fluid Qd as a function of the timet. It can clearly be seen that a first constant flow rate of dialysingfluid Qd_(t) has been set for the test at time point 0 and that a secondconstant flow rate Qd_(b) has been set for the effective dialysistreatment at time point t₁ this having been calculated to ensure that atthe end of the dialysis treatment at time point t₃ all the concentratehas been consumed.

Although the canister 12 is completely empty a residual volume ofconcentrate is left in bag 13. To empty the bag, the control andcalculating unit 24 actuates the proportioning pumps 31 and 32 to drawoff the concentrate remaining in bag 13. The concentrate is mixed withwater in the mixing chamber 27 with the pump 32 supplying this water inthe required ratio by volume. The diluted concentrate then flows to thewaste discharge 10 through the waste pipe 36. Finally, both the canisterand the bag can be removed from the unit and disposed of in a suitablemanner.

In the event that a complication develops during the effective dialysistreatment, the dialyser 1 is disconnected and the dialysing fluid flowsto waste via the by-pass 41. If frequent interruptions occur it can benecessary to prolong the dialysis treatment by an appropriate time inorder to attain the desired effective treatment time of T_(eff).However, in the above exemplary embodiment this is not possible becauseby the end of the treatment at time point t₃ no further quantity ofconcentrate is available.

FIG. 2 b displays the bloodflow Qd_(a) which the doctor would prescribein the case of a conventional dialysis treatment in order to provide aparticular dialysis dosing rate. It is seen clearly that the bloodflowwith the procedure in accordance with the invention is greater than therate of Qd_(a) which would be set by the doctor with the consequencethat the dialysis dosing rate has been increased.

There follows a description of a second exemplary embodiment whichpermits the treatment to be lengthened in the event of one or severalinterruptions. The second exemplary embodiment differs from the firstexample only in that the control and calculating unit 24 of the supplyequipment lays down a different program sequence.

Firstly, a test is carried out as in the case of the first exemplaryembodiment. When the test has been completed and some dialysing fluidhas been disposed of to waste the control and calculating unit 24determines once again the quantity of concentrate present in thecanister 12 or the bag 13 at the beginning of the dialysis treatment(time point t₁) and decides which container is the one to be completelyemptied. It is again assumed that there will be no residual concentrateleft in canister 12.

Then the control and calculating unit 24 determines a dialysing fluidflow rate Qd for a pre-set time interval T_(B1) which should constitutethe essential part of the treatment, the rate being equal to the ratecalculated in the first exemplary embodiment. In principle, however, theflow rate may be greater or less. Nevertheless it should be of such avalue that after the end of the time interval T_(B1) ending at t₂,canister 12 still contains a sufficient volume of concentrate to permitthe treatment to be extended beyond the pre-set time T_(B).

After the end of the time interval T_(B1) the control and calculatingunit 24 of the dialysis unit determines the time period T_(v) of theinterruption of the dialysis treatment. This is the extra time by whichthe treatment should be continued beyond the pre-set treatment timeT_(B).

The control and calculating unit 24 of the supply equipment nowcalculates the remaining treatment time T_(B2)from the pre-set treatmenttime T_(B), the pre-set time interval T_(B1) and the time period T_(v)by which the treatment time should be extended.

Then the control and calculating unit 24 calculates the volume M_(t2) ofconcentrate still held in canister 12 at time point t₂ from the volumeof concentrate M₁ fed into the data input unit 25, i.e. the pre-setvolume of concentrate and the volume of concentrate which was usedduring the test and the pre-set time interval T_(B1).

From the remaining treatment time T_(B2) and the volume of concentrateM_(t2) remaining in canister 12, the control and calculating unit 24then calculates the flow rate Qd_(v) which is to be set in order thatthe canister 12 is completely empty at the end of the treatment. Thisdialysing fluid flow rate is then set for the remaining treatment.

FIGS. 3 a and 3 b also show the volume of concentrate in canister 12 andthe dialysing fluid flow rate Qd as a function of the time t. It can beseen clearly that the treatment will be given over a pre-set timeinterval T_(B1), at first at a dialysing fluid flow rate of Qd_(b1)which is the same as in the first embodiment example and that after atime interval of T_(B1) a lower dialysing fluid flow rate Qd_(v)applies, this being calculated so as to ensure that canister 12 iscompletely empty at the end of the treatment.

Furthermore, it is clear that the blood flow rate with the procedure inaccordance with the invention is greater than blood flow rate Qd_(a)which the doctor would specify in the case of conventional treatment.

At the end of the treatment the residual volume of concentrate in thebag 13 is again diluted with water and allowed to flow to waste with theresult that both the canister and the bag can be removed and disposedof.

To dispose of the residual volume of concentrate, in principle it is notnecessary to use the pipes 26, 28, 29 and 36 and the relevant pumps 30,31 and 32 and the mixing chamber 27. In an alternative embodiment thecontrol and calculating unit 44 switches the haemodialysis unit to acondition where the residual volume of concentrate is disposed of viathe “by-pass”, i.e. the valves 42 and 43 are closed and the valve 40 isopened until the residual volume has been drained to waste. Thisembodiment has the advantage that neither an additional mixing chamberor additional piping and pumps are necessary. Consequently, thisembodiment might be preferred in practice.

It should be noted that the supply equipment in accordance with theinvention permits the most widely different dialysing fluid flow ratesto be pre-set. The only decisive requirement is that the dialysing fluidflow rate be set so as to be compatible with the volume of concentrate,the volumetric ratio and the treatment time.

What is claimed is:
 1. A method for supplying a dialyser of a dialysis unit with a dialysing fluid, the method comprising: making available at least one dialysing fluid concentrate in at least one receiving unit; making available water for diluting the at least one dialysing fluid concentrate; mixing the at least one dialysing fluid concentrate and the water in a first pre-set volumetric ratio to prepare the dialysing fluid; and setting a dialysing fluid flow rate Qd_(b) over a pre-set treatment time T_(B) at a value, which depends upon the presence of a pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment time, the first pre-set volumetric ratio, and the pre-set treatment time T_(B) during the dialysis treatment, such that at the end of the dialysis treatment time the at least one receiving unit is either empty or contains a pre-set residual volume of the at least one dialysing fluid concentrate, wherein the at least one receiving unit contains only said at least one dialysing fluid concentrate.
 2. The method of claim 1, further comprising: determining the pre-set dialysing fluid flow rate Qd_(b) before the commencement of the dialysis treatment from the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time, the first pre-set volumetric ratio, and the pre-set treatment time T_(B) during the dialysis treatment.
 3. The method of claim 1, further comprising: testing the dialysis unit before the commencement of the dialysis treatment time, the testing comprising: determining a volume of the at least one dialysing fluid concentrate in the at least one receiving unit before the commencement of the dialysis treatment time over a pre-set time interval T_(test) from the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time and a volume of the at least one dialysing fluid concentrate used during the pre-set time interval T_(test).
 4. The method of claim 2, wherein at the end of the pre-set treatment time T_(B) the at least one receiving unit contains the pre-set residual volume of the at least one dialysing fluid concentrate, the method further comprising: discharging the pre-set residual volume of the at least one dialysing fluid concentrate to waste.
 5. The method of claim 4, further comprising: diluting the pre-set residual volume of the at least one dialysing fluid concentrate with water in a second pre-set volumetric ratio before the pre-set residual volume is discharged to waste.
 6. The method of claim 2, wherein at the end of the pre-set treatment time T_(B) the at least one receiving unit is empty.
 7. The method of claim 2, further comprising: maintaining the pre-set dialysing fluid flow rate Qd_(b) over the entire treatment time.
 8. The method of claim 2, further comprising: changing the dialysing fluid flow rate Qd_(b) at least once during the treatment time.
 9. A method for supplying a dialyser of a dialysis unit with a dialysing fluid, wherein a dialysis treatment time equals a pre-set time interval T_(B1) plus a remaining dialysis treatment time T_(B2), the method comprising: making available at least one dialysing fluid concentrate in at least one receiving unit; making available water for diluting the at least one dialysing fluid concentrate; mixing the at least one dialysing fluid concentrate and the water in a first pre-set volumetric ratio to prepare the dialysing fluid; and supplying the dialysing fluid to the dialyser at a pre-set dialysing fluid flow rate Qd_(b1) over the pre-set time interval T_(B1) such that an amount of the at least one dialysing fluid concentrate remaining in the at least one receiving unit at the end of the pre-set time interval T_(B1) can be calculated from the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time and an amount of the at least one dialysing fluid concentrate used up during the dialysis treatment time; and setting a dialysing fluid flow rate Qd_(v) over the remaining dialysis treatment time T_(B2) which depends upon a volume of the at least one dialysing fluid concentrate in the at least one receiving unit at the end of the pre-set time interval T_(B1), the first pre-set volumetric ratio, and the remaining dialysis treatment time T_(B2), such that at the end of the dialysis treatment the at least one receiving unit is either empty or contains the pre-set residual volume of the at least one dialysing fluid concentrate, wherein the at least one receiving unit contains only said at least one dialysing fluid concentrate.
 10. The method of claim 9, wherein the dialysis treatment time equals the pre-set treatment time T_(B) plus an extra time interval T_(v).
 11. The method of claim 10, wherein T_(B) is greater than T_(B1).
 12. The method of claim 9, wherein at the end of the remaining dialysis treatment time T_(B2), the at least one receiving unit contains the pre-set residual volume of the at least one dialysing fluid concentrate, the method further comprising: discharging the pre-set residual volume of the at least one dialysing fluid concentrate to waste.
 13. The method of claim 9, wherein at the end of the remaining dialysis treatment time T_(B2) the at least one receiving unit is empty.
 14. The method of claim 9, further comprising: testing the dialysis unit before the commencement of the dialysis treatment time, the testing comprising: determining a volume of the at least one dialysing fluid concentrate in the at least one receiving unit before the commencement of the dialysis treatment time over a pre-set time interval T_(test) from the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time and a volume of the at least one dialysing fluid concentrate used during the pre-set time interval T_(test).
 15. The method of claim 1, further comprising: depositing data describing the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time and/or the first pre-set volumetric ratio, and/or the pre-set treatment time in the form of a barcode on the receiving unit.
 16. The method of claim 15, further comprising: reading the data deposited in the form of a barcode on the receiving unit.
 17. The method of claim 1, further comprising: reading data deposited in the form of a barcode on the receiving unit, the data describing the pre-set volume of the at least one dialysing fluid concentrate at the commencement of the dialysis treatment time and/or the first pre-set volumetric ratio, and/or the pre-set treatment time.
 18. A method for supplying a dialyser of a dialysis unit with a dialysing fluid, the method comprising: making available at least one dialysing fluid concentrate in at least one receiving unit; depositing data describing a pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment period and/or a first pre-set volumetric ratio, and/or a pre-set treatment period in the form of a barcode on the receiving unit; wherein the at least one receiving unit contains only said at least one dialysing fluid concentrate.
 19. An apparatus for supplying a dialyser of a dialysis unit with a dialysing fluid, the apparatus comprising: at least one receiving unit for receiving only at least one dialysing fluid concentrate; means for providing water for a dilution of the at least one dialysing fluid concentrate; means for mixing the at least one dialysing fluid concentrate and the water in a first pre-set volumetric ratio to prepare the dialysing fluid, said means for mixing connected to the at least one receiving unit and configured to receive the at least one dialysing fluid concentrate therefrom; a control and calculating unit configured to set a dialysing fluid flow rate Qd_(b) during a dialysis treatment such that at the end of the pre-set treatment period T_(B), the at least one receiving unit is either empty or contains a pre-set residual volume of the at least one dialysing fluid concentrate; wherein the dialysing fluid flow rate Qd_(b) is dependent upon a pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment period, the first pre-set volumetric ratio, and the pre-set treatment period T_(B), and wherein data describing the pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment period and/or the first pre-set volumetric ratio, and/or the pre-set treatment period are deposited in the form of a barcode on the receiving unit.
 20. The apparatus of claim 19, further comprising a reading device for reading the data deposited in the form of a barcode on the receiving unit.
 21. An apparatus for supplying a dialyser of a dialysis unit with a dialysing fluid, the apparatus comprising: at least one receiving unit for receiving only at least one dialysing fluid concentrate; wherein data describing a pre-set volume of the at least one dialysing fluid concentrate at a commencement of a dialysis treatment period and/or a first pre-set volumetric ratio, and/or a pre-set treatment period are deposited in the form of a barcode on the receiving unit. 